Electron transport chain complex I and mitochondrial fusion regulate ROS for differentiation in Drosophila neural stem cells
Rahul Kumar Verma, Atharva Bhingare, Dnyanesh Dubal, Richa Rikhy · 2026
Read Electron transport chain complex I and mitochondrial fusion regulate ROS for differentiation in Drosophila neural stem cells by Rahul Kumar Verma, Atharva Bhingare, Dnyanesh Dubal, Richa Rikhy (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13385725.txt.
Description
Rahul Kumar Verma and colleagues show how mitochondria control harmful oxygen species during brain stem cell maturation in fruit flies in 2026 work. Both the energy chain's complex I and mitochondrial fusion are needed for differentiation, but their interplay was unknown. Cutting complex I parts left stem cell counts intact yet shrank their lineages and slowed growth.
Damaged energy chains raised reactive oxygen, lowered membrane power, and muted a key growth signal in offspring cells. Blocking the fusion brake restored oxygen balance, growth, and maturation in the depleted cells. Antioxidant support and stronger growth signaling also rescued the defects, which ties fusion and complex I into one control circuit.
Catalog record
| CREATOR | Rahul Kumar Verma, Atharva Bhingare, Dnyanesh Dubal, Richa Rikhy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 87392 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |