Human RNA polymerase III termination favors decomposition over facilitated recycling
Sun Han, Qianmin Wang, Eunho Song, Changwon Kang, Yanhui Xu, Sungchul Hohng · 2026
Read Human RNA polymerase III termination favors decomposition over facilitated recycling by Sun Han, Qianmin Wang, Eunho Song, Changwon Kang, Yanhui Xu, Sungchul Hohng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13385618.txt.
Description
Sun Han and co-authors watch single molecules to see how human RNA polymerase III ends transcription. How this enzyme stops remains poorly understood in detail. The team used fluorescence assays that track one complex at a time.
They found three outcomes at a stop signal: readthrough and two release paths. The main path breaks the whole complex apart at once. A rarer path frees the RNA while the enzyme stays on DNA. Longer runs of thymidine letters favor the rarer recycling path. Hairpins in the RNA boost stopping, but less as they sit farther away. The work redraws how this polymerase finishes its job in human cells.
Catalog record
| CREATOR | Sun Han, Qianmin Wang, Eunho Song, Changwon Kang, Yanhui Xu, Sungchul Hohng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |