The Role and Diagnostic Efficacy of the METTL14/GADD45B m6A Methylation/BDNF Regulatory Axis in Acute Ischemic Stroke
Jin-ying Lai, Jun-hua Lu, Meng-yue Li, Bei-bei Li, Bao-yun Jin, Jiang-jie Hao, Ying Zhao, Ying Lin, Li-qiu Ma, Ren Liu, Shu-fan Zhang, Hong-jun Guan · 2026
Read The Role and Diagnostic Efficacy of the METTL14/GADD45B m6A Methylation/BDNF Regulatory Axis in Acute Ischemic Stroke by Jin-ying Lai, Jun-hua Lu, Meng-yue Li, Bei-bei Li, Bao-yun Jin, Jiang-jie Hao, Ying Zhao, Ying Lin, Li-qiu Ma, Ren Liu, Shu-fan Zhang, Hong-jun Guan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13385536.txt.
Description
Jin-ying Lai and eleven co-authors probe a gene chain as a stroke marker set in a 2026 paper. Acute ischemic stroke still lacks reliable biomarkers. The chain links METTL14, GADD45B, and the growth factor BDNF. An RNA mark called m6A sits at the chain's heart.
Blood tests showed the chain shifted in stroke patients. METTL14 ran high, while GADD45B and BDNF ran low. The RNA mark rose on GADD45B in those patients. All three genes sorted patients from controls quite well. A combined chart with clinical factors performed excellently. The authors propose the chain as a therapy target.
Catalog record
| CREATOR | Jin-ying Lai, Jun-hua Lu, Meng-yue Li, Bei-bei Li, Bao-yun Jin, Jiang-jie Hao, Ying Zhao, Ying Lin, Li-qiu Ma, Ren Liu, Shu-fan Zhang, Hong-jun Guan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |