Scalable hypothalamic neuron differentiation from human pluripotent stem cells suitable for modeling metabolic disorders
Vukasin M. Jovanovic, Narisu Narisu, Lori L. Bonnycastle, David Castellano, Seungmi Ryu, Ravi Tharakan, Kendall T. Mesch, Qiang Chen, Fahrünisa Meryem Betül Erol, Hannah J. Glover, Tingfen Yan, Neelam Sinha, Chaitali Sen, Shu Yang, Dvir Blivis, Daniel F. Bennett, Giovanni Rosales-Soto, Jason Inman, Pinar Ormanoglu, Christopher A. LeClair, Natalie D. Shaw, Menghang Xia, Martin Schneider, Erick O. Hernandez-Ochoa, Michael R. Erdos, Anton Simeonov, Shuibing Chen, Francis S. Collins, Claudia A. Doege, Carlos A. Tristan · 2026
Read Scalable hypothalamic neuron differentiation from human pluripotent stem cells suitable for modeling metabolic disorders by Vukasin M. Jovanovic, Narisu Narisu, Lori L. Bonnycastle, David Castellano, Seungmi Ryu, Ravi Tharakan, Kendall T. Mesch, Qiang Chen, Fahrünisa Meryem Betül Erol, Hannah J. Glover, Tingfen Yan, Neelam Sinha, Chaitali Sen, Shu Yang, Dvir Blivis, Daniel F. Bennett, Giovanni Rosales-Soto, Jason Inman, Pinar Ormanoglu, Christopher A. LeClair, Natalie D. Shaw, Menghang Xia, Martin Schneider, Erick O. Hernandez-Ochoa, Michael R. Erdos, Anton Simeonov, Shuibing Chen, Francis S. Collins, Claudia A. Doege, Carlos A. Tristan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13385436.txt.
Description
Vukasin M. Jovanovic and a large team present a scalable recipe for growing human hypothalamic neurons from stem cells in 2026 work. The hypothalamus steers body balance, and its arcuate nucleus holds appetite-suppressing POMC neurons. Their chemical method enriches those neurons and suits robotic, high-throughput culture systems.
Identity checks used single-cell mapping and gene and chromatin profiling against real human hypothalamus tissue. Lines from several donors behaved alike, and the neurons carried gene patterns tied to body mass measures. The cells also answered insulin, a GLP-1 drug, and glucose shifts, which qualifies the platform for metabolic disease modeling.
Catalog record
| CREATOR | Vukasin M. Jovanovic, Narisu Narisu, Lori L. Bonnycastle, David Castellano, Seungmi Ryu, Ravi Tharakan, Kendall T. Mesch, Qiang Chen, Fahrünisa Meryem Betül Erol, Hannah J. Glover, Tingfen Yan, Neelam Sinha, Chaitali Sen, Shu Yang, Dvir Blivis, Daniel F. Bennett, Giovanni Rosales-Soto, Jason Inman, Pinar Ormanoglu, Christopher A. LeClair, Natalie D. Shaw, Menghang Xia, Martin Schneider, Erick O. Hernandez-Ochoa, Michael R. Erdos, Anton Simeonov, Shuibing Chen, Francis S. Collins, Claudia A. Doege, Carlos A. Tristan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 122358 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |