CD157+ vascular endothelial stem cells represent a conserved subpopulation with an angiogenic gene expression profile
Tomohiro Iba, Taku Wakabayashi, Rie Ito, Ai Sugawara, Satoshi Fujimura, Mika Sawane, Kazuaki Yoshioka, Aya Matsui, Jun-ichi Morishige, Naoto Nagata, Yukinobu Ito, Masafumi Horie, Daichi Maeda, Rica Tanaka, Hitoshi Ando, Nobuyuki Takakura, Hisamichi Naito · 2026
Read CD157+ vascular endothelial stem cells represent a conserved subpopulation with an angiogenic gene expression profile by Tomohiro Iba, Taku Wakabayashi, Rie Ito, Ai Sugawara, Satoshi Fujimura, Mika Sawane, Kazuaki Yoshioka, Aya Matsui, Jun-ichi Morishige, Naoto Nagata, Yukinobu Ito, Masafumi Horie, Daichi Maeda, Rica Tanaka, Hitoshi Ando, Nobuyuki Takakura, Hisamichi Naito (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13385430.txt.
Description
Iba and colleagues define a conserved population of vessel-lining stem cells marked by the protein CD157, in 2026 vascular biology research. Endothelial cells carrying CD157 help renew and maintain blood vessels, but their identity was vague. Comparing gene profiles from mouse and human tissues, the team found these cells share a transcriptional signature enriched for growth genes. The signature is organized by a regulatory network in which the NFAT signaling pathway helps build vessel networks.
Matching human cell clusters sat in the lining of vessels and expressed markers alongside CD157. CD157-positive cells from muscle proliferated more vigorously than their negative counterparts in culture, evidence of stem character. Analysis suggested these cells communicate with neighbors through the CXCL12-CXCR7 signaling axis, a known vessel guidance pathway. Iba proposes the shared signature as a handle for harnessing the vessel's repair crew in regenerative medicine.
Catalog record
| CREATOR | Tomohiro Iba, Taku Wakabayashi, Rie Ito, Ai Sugawara, Satoshi Fujimura, Mika Sawane, Kazuaki Yoshioka, Aya Matsui, Jun-ichi Morishige, Naoto Nagata, Yukinobu Ito, Masafumi Horie, Daichi Maeda, Rica Tanaka, Hitoshi Ando, Nobuyuki Takakura, Hisamichi Naito |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |