WNT signaling in human pluripotent stem cells promotes HDAC2-dependent epigenetic programs and development of retinoic acid-responsive mesoderm
Bao Q. Thai, Elizabeth J. Sargent, Stephanie A. Luff, Colin A. Fields, Jared M. Churko, Jonathan N. Young, Anthony Bosco, Christopher M. Sturgeon, Deepta Bhattacharya · 2026
Read WNT signaling in human pluripotent stem cells promotes HDAC2-dependent epigenetic programs and development of retinoic acid-responsive mesoderm by Bao Q. Thai, Elizabeth J. Sargent, Stephanie A. Luff, Colin A. Fields, Jared M. Churko, Jonathan N. Young, Anthony Bosco, Christopher M. Sturgeon, Deepta Bhattacharya (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13385423.txt.
Description
Bao Q. Thai and colleagues trace how WNT signals prepare stem cells to form hormone-responsive gut-layer tissue in 2026 work. Human pluripotent stem cells can supply immune cells for therapy, but only through the right early tissue steps. Early WNT activation pushed cells toward a marked mesoderm type needed for later T cell growth.
Single-cell gene and chromatin maps charted the path, and network models fingered the regulator HDAC2. Removing HDAC2 blocked the key step, adding more of it boosted yields, and blocking it with drugs had the same blocking effect. The findings suggest practical ways to raise lymphocyte output from stem cells.
Catalog record
| CREATOR | Bao Q. Thai, Elizabeth J. Sargent, Stephanie A. Luff, Colin A. Fields, Jared M. Churko, Jonathan N. Young, Anthony Bosco, Christopher M. Sturgeon, Deepta Bhattacharya |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54908 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |