Rat cell-derived kidney generation via interspecies blastocyst complementation in an Osr1-KO mouse model
Shunsuke Yuri, Ayako Isotani · 2026
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Description
Shunsuke Yuri and Ayako Isotani grow rat kidneys inside mouse embryos in a 2026 study. The long-term goal is to raise transplantable organs from stem cells in animal hosts. Kidneys have resisted this approach, above all when rat cells must build the organ in a mouse.
The team screened mouse models lacking kidney parts to find a truly empty niche. One gene knockout removed both early kidney lineages, leaving space for donor cells. Rat stem cells injected into those embryos contributed strongly to new kidneys. The organs formed mostly from rat cells in the vacant spot. The model opens a workable path for cross-species kidney generation research.
Catalog record
| CREATOR | Shunsuke Yuri, Ayako Isotani |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |