Revisiting hypocholesterolemia during prolonged sepsis: From targeted cholesterol repletion to unresolved adrenal and muscle dysfunction
Lauren De Bruyn, Fien Van Beek, Sarah Vander Perre, Sarah Derde, Inge Derese, Lies Pauwels, Greet Van den Berghe, Lies Langouche · 2026
Read Revisiting hypocholesterolemia during prolonged sepsis: From targeted cholesterol repletion to unresolved adrenal and muscle dysfunction by Lauren De Bruyn, Fien Van Beek, Sarah Vander Perre, Sarah Derde, Inge Derese, Lies Pauwels, Greet Van den Berghe, Lies Langouche (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13384042.txt.
Description
Lauren De Bruyn and colleagues test cholesterol top-ups during long sepsis in mouse studies in 2026 work. Blood cholesterol falls sharply in sepsis and low levels track with worse outcomes, but cause and effect were unclear. Septic mice received five days of infusions rich in LDL or HDL cholesterol, or a placebo.
Infusions raised the targeted blood fractions and eased cholesterol loss in the adrenal glands. Muscle mass, force, and fiber cholesterol did not improve, though, and adrenal structure and hormone response stayed impaired. The authors conclude that repletion alone does not fix the adrenal and muscle problems of prolonged sepsis.
Catalog record
| CREATOR | Lauren De Bruyn, Fien Van Beek, Sarah Vander Perre, Sarah Derde, Inge Derese, Lies Pauwels, Greet Van den Berghe, Lies Langouche |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56307 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |