Development of a sheep model of knee osteoarthritis and preliminary magnetic resonance–guided focused ultrasound evaluation
Xuejun Du, Andrew Spiteri, Arik Hananel, Abhijit Dighe, Richard J Price, Xinlin Yang, Quanjun Cui · 2026
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Description
Xuejun Du's team built a sheep model of knee osteoarthritis and piloted focused ultrasound for pain, in a 2026 study. Knee osteoarthritis lacks good non-surgical pain options, and large-animal models matching human joint anatomy were needed. The team induced osteoarthritis in the right knees of nine sheep with monosodium iodoacetate injections on days 8 and 29, tracking them for 12 weeks.
Treated knees developed joint space narrowing, osteophytes, cartilage erosion, and disrupted architecture, confirming the model. Only two sheep developed persistent pain behaviors, and in those, MRI-guided focused ultrasound between weeks 6 and 8 improved pain scores and activity without added harm. The pilot supports larger controlled trials of ultrasound pain therapy.
Catalog record
| CREATOR | Xuejun Du, Andrew Spiteri, Arik Hananel, Abhijit Dighe, Richard J Price, Xinlin Yang, Quanjun Cui |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |