Early diabetes‐like phenotypes in germ‐free mice induced by gut microbiota from patients with type 2 diabetes
Jianghao Feng, Xing Liu, Hua Zhu, Yun Yang, Wei Liu, Xiaoliang Jiang, Zhiwei Yang · 2026
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Description
Jianghao Feng and co-authors test whether gut microbes from people with type 2 diabetes can trigger early disease signs in 2026 work. Germ-free mice received pooled microbes from diabetic or healthy human donors, creating two groups watched for ten weeks. Blood sugar handling, insulin, and microbe shifts were tracked over that period.
Mice with diabetic-donor microbes developed worsening glucose tolerance and lower insulin, without sustained high fasting sugar. Their gut communities diverged early and stayed out of balance, with matching shifts in stool and blood chemicals. Two compounds, cholic acid and L-Dopa, fell in both sample types, which the authors link to the early disease pattern.
Catalog record
| CREATOR | Jianghao Feng, Xing Liu, Hua Zhu, Yun Yang, Wei Liu, Xiaoliang Jiang, Zhiwei Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41032 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |