Tetrandrine-based in situ vaccination via multifunctional Mn²⁺-hyaluronic acid hydrogel loading gelatinase-responsive nanoparticles
Wanru Wang, Shujun Song, Dongliang Han, Yuling Qiu, Dan Lei, Xuxuan Gu, Haoyue Qi, Hanxi Zhang, Lanqi Cen, Jie Shao, Xiaoping Qian, Wenxiu Chen, Lixia Yu, Baorui Liu, Li Xie, Rutian Li · 2026
Read Tetrandrine-based in situ vaccination via multifunctional Mn²⁺-hyaluronic acid hydrogel loading gelatinase-responsive nanoparticles by Wanru Wang, Shujun Song, Dongliang Han, Yuling Qiu, Dan Lei, Xuxuan Gu, Haoyue Qi, Hanxi Zhang, Lanqi Cen, Jie Shao, Xiaoping Qian, Wenxiu Chen, Lixia Yu, Baorui Liu, Li Xie, Rutian Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13383491.txt.
Description
Wanru Wang and co-authors build a gel that turns a breast tumor into its own vaccine in this 2026 study. Cancer vaccines made inside the tumor can train the immune system where it matters, but drugs leak away fast and the tumor setting resists change. Their gel is injected into the tumor and holds tiny drug particles that dissolve when tumor enzymes appear.
The gel carries a plant-derived drug plus manganese, which lets doctors track the depot on scans. In mice, it slowed tumor growth and lengthened life with no clear harm. Treating one tumor also shrank a second, untreated tumor and cut lung spread. Tests showed more mature immune sentry cells and more killer T cells inside tumors, plus signs of vessel reshaping.
Catalog record
| CREATOR | Wanru Wang, Shujun Song, Dongliang Han, Yuling Qiu, Dan Lei, Xuxuan Gu, Haoyue Qi, Hanxi Zhang, Lanqi Cen, Jie Shao, Xiaoping Qian, Wenxiu Chen, Lixia Yu, Baorui Liu, Li Xie, Rutian Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |