High lipoprotein(a) results in overestimation of BQ-based low-density lipoprotein-cholesterol measurement
Azusa Yamazaki, Yuna Hakii, Masumi Ai, Shuji Miyake, Junichiro Takahashi, Akira Yoshimoto, Takahiro Kameda, Naoya Ichimura, Shuji Tohda, Shinji Yokoyama, Ryunosuke Ohkawa · 2026
Read High lipoprotein(a) results in overestimation of BQ-based low-density lipoprotein-cholesterol measurement by Azusa Yamazaki, Yuna Hakii, Masumi Ai, Shuji Miyake, Junichiro Takahashi, Akira Yoshimoto, Takahiro Kameda, Naoya Ichimura, Shuji Tohda, Shinji Yokoyama, Ryunosuke Ohkawa (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13383217.txt.
Description
Azusa Yamazaki and co-authors show how high lipoprotein(a) levels distort a common cholesterol test in 2026 work. Standard LDL cholesterol assays rely on density separation, and a protein part of lipoprotein(a) can shift where particles settle. The team compared routine assay results with a chromatography method across 1,560 human samples.
Routine values ran higher than the reference method as lipoprotein(a) rose, and the gap grew clearly above a set level. A formula-based VLDL estimate moved the opposite way with rising levels. The authors conclude that density-based assays overstate LDL cholesterol when lipoprotein(a) is high, a caution for labs and clinicians reading results.
Catalog record
| CREATOR | Azusa Yamazaki, Yuna Hakii, Masumi Ai, Shuji Miyake, Junichiro Takahashi, Akira Yoshimoto, Takahiro Kameda, Naoya Ichimura, Shuji Tohda, Shinji Yokoyama, Ryunosuke Ohkawa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50383 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |