Anisotropic NMR as a Crucial Tool for Differentiation of Epimers With High Conformational Flexibility
Juan Carlos C Fuentes‐Monteverde, Abel M Forero, Nilamoni Nath, Antonio Hernández Daranas, Carlos Jiménez, Jaime Rodríguez, Christian Griesinger · 2026
Read Anisotropic NMR as a Crucial Tool for Differentiation of Epimers With High Conformational Flexibility by Juan Carlos C Fuentes‐Monteverde, Abel M Forero, Nilamoni Nath, Antonio Hernández Daranas, Carlos Jiménez, Jaime Rodríguez, Christian Griesinger (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13382916.txt.
Description
Juan Carlos Fuentes-Monteverde's team used anisotropic NMR to tell apart two flexible epimers, in a 2026 chemistry study. The pair of tetraprenyltoluquinol meroterpenoids differs only at carbon 3, with two distant stereoclusters and high flexibility blurring standard NMR signatures. DP4-based methods failed to separate them.
The team mapped the conformational space of both epimers, then fit carbon residual chemical shift anisotropies and residual dipolar couplings measured in poly-HEMA gels. The refined fit assigned the relative configuration of each epimer. The method offers a path for natural products whose floppy shapes defeat simpler NMR assignment tools.
Catalog record
| CREATOR | Juan Carlos C Fuentes‐Monteverde, Abel M Forero, Nilamoni Nath, Antonio Hernández Daranas, Carlos Jiménez, Jaime Rodríguez, Christian Griesinger |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |