Stable and tunable expression of human peripheral myelin protein 22 in Rat Schwann cells
Mason C. Wilkinson, Katherine M. Stefanski, Pramod S. Gowda, Bruce D. Carter, Charles R. Sanders · 2026
Read Stable and tunable expression of human peripheral myelin protein 22 in Rat Schwann cells by Mason C. Wilkinson, Katherine M. Stefanski, Pramod S. Gowda, Bruce D. Carter, Charles R. Sanders (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13382790.txt.
Description
Mason C. Wilkinson and co-authors build a rat Schwann cell line whose human PMP22 output can be dialed up or down in 2026 work. Extra or missing copies of the PMP22 gene cause the most common forms of Charcot-Marie-Tooth disease, a nerve disorder. Fine control of the protein level has been hard to achieve in lab cells.
Adding the drug doxycycline set the tagged protein level, with peak output at mid-range drug doses. At high levels, less protein reached the cell surface and more gathered in clumps inside the cell. The line gives researchers a clean tool to study how excess PMP22 may damage the insulation around nerves.
Catalog record
| CREATOR | Mason C. Wilkinson, Katherine M. Stefanski, Pramod S. Gowda, Bruce D. Carter, Charles R. Sanders |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31534 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |