DNA Binding Properties of Novel Pyrrolyl Quinones Derivatives: Insights from Spectroscopic, Electrophoretic and Computational Studies
Sandra G. Barbosa-Muñoz, Melissa Tapia-Juárez, Diana S. Ramírez-Guzmán, Salvador Gallardo-Alfonzo, Fabián Orozco-López, César R. Solorio-Alvarado, Carlos J. Cortés-García, Luis Chacón-García · 2026
Read DNA Binding Properties of Novel Pyrrolyl Quinones Derivatives: Insights from Spectroscopic, Electrophoretic and Computational Studies by Sandra G. Barbosa-Muñoz, Melissa Tapia-Juárez, Diana S. Ramírez-Guzmán, Salvador Gallardo-Alfonzo, Fabián Orozco-López, César R. Solorio-Alvarado, Carlos J. Cortés-García, Luis Chacón-García (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13382747.txt.
Description
Sandra G. Barbosa-Muñoz and colleagues present a new family of pyrrolyl quinone compounds and test how they bind DNA in 2026 work. The compounds were built from a simple quinone through a series of addition and substitution steps. Further reactions with other building blocks widened the set of structures for testing.
Light-based tests, gel runs, thickness measures, and computer docking all pointed to real contact with DNA. Such binding matters because compounds that sit on DNA can block copying enzymes tied to fast cell growth. The authors frame the scaffold as a useful starting point for later drug design and for tools that detect target molecules.
Catalog record
| CREATOR | Sandra G. Barbosa-Muñoz, Melissa Tapia-Juárez, Diana S. Ramírez-Guzmán, Salvador Gallardo-Alfonzo, Fabián Orozco-López, César R. Solorio-Alvarado, Carlos J. Cortés-García, Luis Chacón-García |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40480 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |