Hematological Toxicity and Bone Marrow Dose-Volume Effects in Chemotherapy-Naïve Patients Treated With Whole Pelvic and Para-aortic Lymph Node Radiation Therapy For Pathologic Pelvic Lymph Node–Positive Prostate Cancer
Julie den Hartog, Gert De Meerleer, Annouschka Laenen, Robin De Roover, Steven Joniau, Koen Slabbaert, Ann Janssens, Herlinde Dumez, Alexander Giesen, Kato Rans · 2026
Read Hematological Toxicity and Bone Marrow Dose-Volume Effects in Chemotherapy-Naïve Patients Treated With Whole Pelvic and Para-aortic Lymph Node Radiation Therapy For Pathologic Pelvic Lymph Node–Positive Prostate Cancer by Julie den Hartog, Gert De Meerleer, Annouschka Laenen, Robin De Roover, Steven Joniau, Koen Slabbaert, Ann Janssens, Herlinde Dumez, Alexander Giesen, Kato Rans (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13382578.txt.
Description
Julie den Hartog's team tracked blood toxicity from pelvic and para-aortic radiation in prostate cancer, in a 2026 study. Whole pelvic radiation plus hormone therapy improves prostate cancer survival in node-positive disease, and adding para-aortic radiation is under trial. The team analyzed the first 75 Leuven patients in the PART trial, all on 24 months of hormone therapy.
At a median 57 months of follow-up, no blood toxicity forced a treatment break. All blood counts fell after radiation, but grade 4 toxicity was limited to lymphopenia, and no severe anemia or platelet toxicity appeared. Larger low-dose volumes to pelvic marrow tracked with greater late lymphocyte decline, giving planners dose limits to protect blood counts.
Catalog record
| CREATOR | Julie den Hartog, Gert De Meerleer, Annouschka Laenen, Robin De Roover, Steven Joniau, Koen Slabbaert, Ann Janssens, Herlinde Dumez, Alexander Giesen, Kato Rans |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |