Severe Gastrointestinal Graft-versus-Host Disease Following Haploidentical Stem Cell Transplantation Presenting With Passage of a Colonic Cast
Faisal Abubaker, Mariam Adnan, Noora Almannai, Noora Butti, Eman Aljufairi · 2026
Read Severe Gastrointestinal Graft-versus-Host Disease Following Haploidentical Stem Cell Transplantation Presenting With Passage of a Colonic Cast by Faisal Abubaker, Mariam Adnan, Noora Almannai, Noora Butti, Eman Aljufairi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13382261.txt.
Description
Abubaker and colleagues report a case of gut graft-versus-host disease after a half-matched stem cell transplant, in a 2026 hematology case report. A 67-year-old man received the transplant for myelodysplastic syndrome with excess blasts, then developed graft-versus-host disease in which donor immune cells attack the gut. His course compounded refractory blood counts, infections, fluid around the lungs, and liver dysfunction. The gut disease resisted steroids, the usual brake on the donor immune attack.
An event marked the injury: the patient passed a colonic cast, a sheet of sloughed gut lining reflecting loss of the gut surface. Treatment escalated through corticosteroids, calcineurin inhibition, ruxolitinib, and extracorporeal photopheresis, where blood is treated with light, yet he deteriorated and died. Abubaker presents the cast as a sign of mucosal destruction, and the case as a warning about steroid-refractory disease in half-matched transplant settings.
Catalog record
| CREATOR | Faisal Abubaker, Mariam Adnan, Noora Almannai, Noora Butti, Eman Aljufairi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 9 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |