GPAT4 regulates antitumor immune response through activating the mtDNA-cGAS axis in cancer cells
Zi-Lun Ruan, Wei Liang, Yu-Tong Gong, Wei-Tao Guan, Xuan-Ang Zhou, Kai Jiang, Qing Yang, Ming-Ming Hu · 2026
Read GPAT4 regulates antitumor immune response through activating the mtDNA-cGAS axis in cancer cells by Zi-Lun Ruan, Wei Liang, Yu-Tong Gong, Wei-Tao Guan, Xuan-Ang Zhou, Kai Jiang, Qing Yang, Ming-Ming Hu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13382030.txt.
Description
Zi-Lun Ruan and colleagues report a 2026 study identifying a fat-making enzyme as a brake on anti-tumour immunity. Switching on a tumour's own alarm signals can draw in immune cells and help immunotherapy work. The enzyme in question, called GPAT4, is abundant in many tumours, including pancreatic and breast cancers, where immune entry is poor.
In mouse experiments, tumours lacking the enzyme grew more slowly and filled with more killer immune cells. The reason was stress in the tumours' energy centres, which leaked their DNA into the cell and triggered an alarm pathway. Notably, this effect did not depend on the enzyme's usual chemical job. Blocking it could be a new way to warm up cold tumours.
Catalog record
| CREATOR | Zi-Lun Ruan, Wei Liang, Yu-Tong Gong, Wei-Tao Guan, Xuan-Ang Zhou, Kai Jiang, Qing Yang, Ming-Ming Hu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83361 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |