Association of pyrazinamide resistance in Mycobacterium tuberculosis with mutations in rpoB, katG, and inhA genes
Kartiki Srivastava, Salman Khan, Rajniti Prasad, Sada Nand Pandey, Shampa Anupurba · 2026
Read Association of pyrazinamide resistance in Mycobacterium tuberculosis with mutations in rpoB, katG, and inhA genes by Kartiki Srivastava, Salman Khan, Rajniti Prasad, Sada Nand Pandey, Shampa Anupurba (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13381933.txt.
Description
Kartiki Srivastava and co-authors report a 2026 study of drug resistance in tuberculosis. Multi-drug resistant forms of the disease often fail treatment. The shorter oral cure for these forms includes pyrazinamide, so knowing whether the drug still works is key to good care.
The team tested strains from 780 positive samples and found 195 that resisted first-line drugs. Of those, 107 also resisted pyrazinamide while 88 stayed sensitive to it. They checked gene changes tied to resistance in four genes. The most common changes were in the rpoB, katG, and inhA genes. Culture tests with a liquid system confirmed the patterns. The results link certain gene changes to pyrazinamide failure and can steer drug choice.
Catalog record
| CREATOR | Kartiki Srivastava, Salman Khan, Rajniti Prasad, Sada Nand Pandey, Shampa Anupurba |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |