DNA-PK-mediated CRTC2 phosphorylation promotes NHEJ and suppresses antitumor immunity via relocation to repair complexes
Fangdi Zou, Zhiqi Yao, Xiaohan Dong, Yang Liu, Zhanjie Xiu, Meixi Wang, Xiaofeng Liu, Xinlu Wang, Lin Sun, Jian Wang, Shuai Ma, Heng Zhang, Kaishun Hu, Yan Sun, Kexin Chen, Zhiyong Yuan, Lei Shi, Zhiqiang Wu, Zeyun Mi · 2026
Read DNA-PK-mediated CRTC2 phosphorylation promotes NHEJ and suppresses antitumor immunity via relocation to repair complexes by Fangdi Zou, Zhiqi Yao, Xiaohan Dong, Yang Liu, Zhanjie Xiu, Meixi Wang, Xiaofeng Liu, Xinlu Wang, Lin Sun, Jian Wang, Shuai Ma, Heng Zhang, Kaishun Hu, Yan Sun, Kexin Chen, Zhiyong Yuan, Lei Shi, Zhiqiang Wu, Zeyun Mi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13381860.txt.
Description
Fangdi Zou and co-authors uncover a double life of a gene switch in damaged DNA in a 2026 study. When DNA breaks, cells halt gene reading to focus on repair. A reading activator called CRTC2, it turns out, moonlights in the repair crew. A sensor protein recruits it to breaks, where it helps assemble the main end-joining repair machine.
That machine then tags CRTC2, loosening it from its reading job and locking it into the repair complex, a self-reinforcing loop. Removing CRTC2 made liver cancer cells far more sensitive to radiation and woke immune attack on tumors. Targeting it in mice sensitized tumors to combined radiation and immune therapy. The switch links silencing genes to fixing them, and offers a drug target.
Catalog record
| CREATOR | Fangdi Zou, Zhiqi Yao, Xiaohan Dong, Yang Liu, Zhanjie Xiu, Meixi Wang, Xiaofeng Liu, Xinlu Wang, Lin Sun, Jian Wang, Shuai Ma, Heng Zhang, Kaishun Hu, Yan Sun, Kexin Chen, Zhiyong Yuan, Lei Shi, Zhiqiang Wu, Zeyun Mi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 105 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |