Advanced nanoformulations of NUAK1 regulate NLRP3 inflammasome for preeclampsia management in mice
Peiyue Jiang, Xue Ying, Zhi Li, Weidong Fei, Yao Yao, Jia Xu, Hetong Li, Lujiao Chen, Qiong Luo · 2026
Read Advanced nanoformulations of NUAK1 regulate NLRP3 inflammasome for preeclampsia management in mice by Peiyue Jiang, Xue Ying, Zhi Li, Weidong Fei, Yao Yao, Jia Xu, Hetong Li, Lujiao Chen, Qiong Luo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13381823.txt.
Description
Peiyue Jiang and eight co-authors test a nanoparticle therapy for preeclampsia in mice. Preeclampsia is a severe pregnancy problem driven by placental dysfunction and oxidative stress, with no targeted therapy yet. Their particles are lipid based, modified with folic acid, and loaded with polydopamine plus a kinase called NUAK1.
In cells under stress, they lower reactive oxygen species and hold back the NLRP3 inflammasome. They also promote protective autophagy and cut cell death. In a drug induced mouse model of the disease, treatment makes placental structure and fetal growth better. This dual action, calming the inflammasome while boosting autophagy, offers a promising path ahead.
Catalog record
| CREATOR | Peiyue Jiang, Xue Ying, Zhi Li, Weidong Fei, Yao Yao, Jia Xu, Hetong Li, Lujiao Chen, Qiong Luo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 112 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |