CD4+ T cell protection against murine Salmonella infection is female-specific and estrogen-dependent
Shaina J D’Souza, Rebecca M Horowitz, Louay Bachnak, Victoria E Immethun, Matthew S Godwin, Charlotte M Hankin, Vanessa M Limbert, David L Bauer, Alex J Plaisance, Avery M Burke, Lisa A Morici, Hyemin Lee, Hua Lu, Ryan Craig, Jonathan R Kurtz, Sophia A Blessinger, Sarah H Lindsey, Franck Mauvais-Jar · 2026
Read CD4+ T cell protection against murine Salmonella infection is female-specific and estrogen-dependent by Shaina J D’Souza, Rebecca M Horowitz, Louay Bachnak, Victoria E Immethun, Matthew S Godwin, Charlotte M Hankin, Vanessa M Limbert, David L Bauer, Alex J Plaisance, Avery M Burke, Lisa A Morici, Hyemin Lee, Hua Lu, Ryan Craig, Jonathan R Kurtz, Sophia A Blessinger, Sarah H Lindsey, Franck Mauvais-Jar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13381739.txt.
Description
Shaina D'Souza and a large team find that a key immune cell guards female mice, but not males, against a gut germ in a 2026 study. The cells, a helper type of T cell, are known to curb germs that hide inside cells. How sex shapes that guard had been poorly mapped.
More male mice died from the germ than females, though males held more of the guard cells late on. Mice stripped of those cells flipped the pattern, so the cells help one sex and harm the other. Giving the cells back saved females but hurt males. A female hormone drove the guard effect, and dosing it restored the cells' good work.
Catalog record
| CREATOR | Shaina J D’Souza, Rebecca M Horowitz, Louay Bachnak, Victoria E Immethun, Matthew S Godwin, Charlotte M Hankin, Vanessa M Limbert, David L Bauer, Alex J Plaisance, Avery M Burke, Lisa A Morici, Hyemin Lee, Hua Lu, Ryan Craig, Jonathan R Kurtz, Sophia A Blessinger, Sarah H Lindsey, Franck Mauvais-Jar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |