Gut microbiota-induced perturbation in bile acids alter keratinocyte lipid metabolism via FXR-NQO1 signaling in psoriasis
Panpan Lian, Renwei Lu, Chaode Gu, Junaid Wazir, Wentong Wang, Yangyongyi Zong, Yun Xia, Jie Ni, Huimei Chen, Enrico Petretto, Eckardt Treuter, Rongrong Fan, Airong Yang, Zhonglan Su, Hongwei Wang, Zhiqiang Huang · 2026
Read Gut microbiota-induced perturbation in bile acids alter keratinocyte lipid metabolism via FXR-NQO1 signaling in psoriasis by Panpan Lian, Renwei Lu, Chaode Gu, Junaid Wazir, Wentong Wang, Yangyongyi Zong, Yun Xia, Jie Ni, Huimei Chen, Enrico Petretto, Eckardt Treuter, Rongrong Fan, Airong Yang, Zhonglan Su, Hongwei Wang, Zhiqiang Huang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13381536.txt.
Description
Panpan Lian, Renwei Lu, Chaode Gu, and a wider team wrote this research paper, published in 2026. It traces a path from gut bacteria to psoriasis, the scaly skin disease, through bile acids and a sensor protein in skin cells.
People and mice with psoriasis showed disturbed bile acid patterns, and their skin cells carried more of a receptor called FXR. Switching that receptor on with a bile acid eased symptoms in mice, in part by helping skin cells burn fat and resist oxidative stress. Removing the receptor from skin cells made the disease worse. Gut bacteria gone off balance seemed to drive the bile acid changes. The authors suggest that fixing gut bacteria or targeting this pathway could become a treatment route.
Catalog record
| CREATOR | Panpan Lian, Renwei Lu, Chaode Gu, Junaid Wazir, Wentong Wang, Yangyongyi Zong, Yun Xia, Jie Ni, Huimei Chen, Enrico Petretto, Eckardt Treuter, Rongrong Fan, Airong Yang, Zhonglan Su, Hongwei Wang, Zhiqiang Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 85 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |