The use of cultured human hepatocytes as a test system to evaluate cell proliferation as a key event in nongenotoxic carcinogenesis
David E Cowie, Samuel M Cohen, Manuela Goettel, Brian G Lake, Stephanie Nadzialek, Uku Rooni, Maaike E Schutte, Helen Tinwell, Josh Turiccki, Tomoya Yamada, Christian Strupp · 2026
Read The use of cultured human hepatocytes as a test system to evaluate cell proliferation as a key event in nongenotoxic carcinogenesis by David E Cowie, Samuel M Cohen, Manuela Goettel, Brian G Lake, Stephanie Nadzialek, Uku Rooni, Maaike E Schutte, Helen Tinwell, Josh Turiccki, Tomoya Yamada, Christian Strupp (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13379485.txt.
Description
David Cowie and co-authors evaluated cultured human liver cells in 2026 as a test system for chemicals that may cause cancer without damaging DNA. Cell division in the liver is a key step in that pathway, and rodent tests mislead because some triggers divide rodent but not human cells.
Thirty-nine frozen human liver cell preparations, from donors aged ten months to eighty years, were tested in two labs. Growth factors reliably switched on DNA copying in all preparations. Two classes of receptor-activating chemicals that divide rodent liver cells did not raise copying in human cells. Results did not depend on donor sex or age. The system looks reproducible and fit for formal validation.
Catalog record
| CREATOR | David E Cowie, Samuel M Cohen, Manuela Goettel, Brian G Lake, Stephanie Nadzialek, Uku Rooni, Maaike E Schutte, Helen Tinwell, Josh Turiccki, Tomoya Yamada, Christian Strupp |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |