Aging in a highly polluted world: challenges and solutions to prevent Alzheimer’s disease
Jose L. Domingo · 2026
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Description
Domingo reviews the evidence that pollution feeds Alzheimer's disease, in a 2026 neurology synthesis. Alzheimer's is the world's commonest neurodegenerative disorder, and its burden is projected to more than double by 2050, passing 150 million people. Most cases arise late in life from genes interacting with changeable exposures. The review assembles findings from human cohorts, animal experiments, and cell systems across pollutant classes: airborne particles, heavy metals, pesticides, PFAS chemicals, and microplastics now found in human tissues.
The 2024 Lancet Commission on dementia listed 14 changeable risk factors, with air pollution explicitly among them, framing exposure control as prevention. Domingo highlights studies finding Alzheimer-type brain changes in children and young adults living amid heavy city pollution, suggesting damage begins decades before symptoms. Shared mechanisms run through inflammation, oxidative stress, and blood vessel injury. The review argues that cleaning air and water is a concrete lever against a disease doctors still cannot cure.
Catalog record
| CREATOR | Jose L. Domingo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 97 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |