From raw data to meaningful information: a robust but flexible method to assess in vitro assay responses—lessons learned from a novel Dicentrarchus labrax estrogen screen test
Sylvain Slaby, Aurélie Duflot, Géraldine Maillet, Jérôme Couteau, Christophe Minier, Anne-Sophie Allonier-Fernandes, Patrícia I. S. Pinto, Thomas Knigge, Tiphaine Monsinjon · 2026
Read From raw data to meaningful information: a robust but flexible method to assess in vitro assay responses—lessons learned from a novel Dicentrarchus labrax estrogen screen test by Sylvain Slaby, Aurélie Duflot, Géraldine Maillet, Jérôme Couteau, Christophe Minier, Anne-Sophie Allonier-Fernandes, Patrícia I. S. Pinto, Thomas Knigge, Tiphaine Monsinjon (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13379407.txt.
Description
Nine authors set out in 2026 a firm but flexible way to judge lab assay results, drawn from a new estrogen screen in sea bass. Assay data are often read with weak stats, small samples, or vague rules. Their method sets cut points from a normal curve fit, a habit borrowed from clinical work.
Cut points were tested on the fish screen and matched against a standard OECD method and non-parametric tests. The curve-based cuts made calls simpler and more stable, above all for non-model species with few reference drugs. The authors warn that the base data set used for cuts must be large enough.
Catalog record
| CREATOR | Sylvain Slaby, Aurélie Duflot, Géraldine Maillet, Jérôme Couteau, Christophe Minier, Anne-Sophie Allonier-Fernandes, Patrícia I. S. Pinto, Thomas Knigge, Tiphaine Monsinjon |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |