Beyond the Alpha and Omega: Redefining the Peroxisome Proliferator–Activated Receptor α Gut–Liver Axis in Intestinal Failure–Associated Liver Disease
Chaowapong Jarasvaraparn, Brian J. Debosch, Abigail E. Russi · 2026
Read Beyond the Alpha and Omega: Redefining the Peroxisome Proliferator–Activated Receptor α Gut–Liver Axis in Intestinal Failure–Associated Liver Disease by Chaowapong Jarasvaraparn, Brian J. Debosch, Abigail E. Russi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13379324.txt.
Description
Chaowapong Jarasvaraparn and two co-authors wrote a 2026 commentary on liver harm in children and adults who lose much of their small bowel. With too little gut, patients rely on vein feeding, and the liver often suffers over time. The cause was once blamed on vein feeding and stalled bile alone. It is now seen as a break in the gut-liver axis.
The commentary discusses a mouse study by Phelps and co-authors on fat type in food. Mice fed omega-3 fats after bowel removal survived better and gained back more weight than mice on omega-6 fats. Their remaining gut also shifted toward an upper-gut pattern of genes. The writers link this to a receptor pathway in the gut-liver axis.
Catalog record
| CREATOR | Chaowapong Jarasvaraparn, Brian J. Debosch, Abigail E. Russi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 4 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |