Fructose‐Based Single‐Chain Polymer Nanoparticles for GLUT1–Mediated Delivery: Impact of Polymer Design on Uptake and In Vivo Performance
Hoang Yen Vo, Linqing Tian, Qiaoyun Wang, Evelyn Szabo, Rebecca Y. Lai, Fariba Dehghani, Martina H. Stenzel · 2026
Read Fructose‐Based Single‐Chain Polymer Nanoparticles for GLUT1–Mediated Delivery: Impact of Polymer Design on Uptake and In Vivo Performance by Hoang Yen Vo, Linqing Tian, Qiaoyun Wang, Evelyn Szabo, Rebecca Y. Lai, Fariba Dehghani, Martina H. Stenzel (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13378471.txt.
Description
Hoang Yen Vo and colleagues present a 2026 study of tiny polymer particles designed to carry material into cells through a sugar gateway. Each particle is a single folded polymer chain, shaped somewhat like a tadpole, with a head and a tail. One part was based on a common polymer called PEG, and the other carried the sugar fructose.
Particles with the fructose part on the outside were taken up by cells far more than those with it tucked inside. Uptake was highest in the cells that carry the most sugar gateways, and blocking one gateway, GLUT1, largely stopped it. The work shows that surface placement matters as much as content when designing such carriers.
Catalog record
| CREATOR | Hoang Yen Vo, Linqing Tian, Qiaoyun Wang, Evelyn Szabo, Rebecca Y. Lai, Fariba Dehghani, Martina H. Stenzel |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41555 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |