Loss of cold shock domain-containing protein E1 (CSDE1) function enhances mRNA stability of interleukin-6 and promotes malignant transformation in endometrial cancer cells
Yuanlin Liu, Lianqiao Qiao, Xiaoli Wen, Mengfei Wang, Junyuan Li, Yan Ding, Han Tao, Yilin Dai, Luhui Wang, Kun Gao, Xiaoping Wan · 2026
Read Loss of cold shock domain-containing protein E1 (CSDE1) function enhances mRNA stability of interleukin-6 and promotes malignant transformation in endometrial cancer cells by Yuanlin Liu, Lianqiao Qiao, Xiaoli Wen, Mengfei Wang, Junyuan Li, Yan Ding, Han Tao, Yilin Dai, Luhui Wang, Kun Gao, Xiaoping Wan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13378120.txt.
Description
Yuanlin Liu and others show that losing CSDE1 stabilises interleukin-6 messenger RNA and drives endometrial cancer in a 2026 study. RNA-binding proteins control gene expression after gene reading, and CSDE1 is mutated or dysregulated in several cancers, yet its role in endometrial cancer was unclear. The Cancer Genome Atlas data were checked, and CRISPR knockout lines were built.
CSDE1 was frequently mutated and clearly lowered in endometrial tumours against normal tissue. Losing CSDE1 markedly raised proliferation, migration, invasion, and epithelial-to-mesenchymal switch, linked to longer-lived interleukin-6 messenger RNA. Silencing interleukin-6 or blocking it with siltuximab rescued the malignant traits. The work presents CSDE1 loss and interleukin-6 signals as a treatment axis in endometrial cancer.
Catalog record
| CREATOR | Yuanlin Liu, Lianqiao Qiao, Xiaoli Wen, Mengfei Wang, Junyuan Li, Yan Ding, Han Tao, Yilin Dai, Luhui Wang, Kun Gao, Xiaoping Wan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |