Comparative genomics reveals polyphyletic emergence of methicillin-resistant Staphylococcus aureus ST152 from a diverse methicillin-susceptible population in ghana
Brown Beckley, Vincent Amarh, Adesola Olalekan, Innocent Afeke · 2026
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Description
Brown Beckley, Vincent Amarh, Adesola Olalekan, and Innocent Afeke trace drug resistance in a staph lineage in Ghana in a 2026 study. Staphylococcus aureus is a major infection threat, and one lineage, ST152, has become dominant there while carrying a potent toxin gene. The team asked how methicillin resistance arose inside that lineage.
They analyzed close to three hundred public genomes of the germ from Ghana, from people and animals. ST152 made up more than a quarter of them. Family trees showed resistance arose many times on its own, as the resistance cassette was picked up again and again. Even so, one resistant branch now dominates. That branch carries extra resistance genes, a plasmid type, and a glue protein gene that may aid spread. Drug-sensitive strains sat inside resistant clusters, showing how fluid the trait is.
Catalog record
| CREATOR | Brown Beckley, Vincent Amarh, Adesola Olalekan, Innocent Afeke |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |