H3K9me3 controls epidermis morphogenesis by regulating RNA Pol II dynamics at developmental promoters and enhancers
Chris Ke Bai, Gopal Chovatiya, Emily Janine Pollack, Yu-Ching Liao, Ashley Nayeon Kim, Tudorita Tumbar · 2026
Read H3K9me3 controls epidermis morphogenesis by regulating RNA Pol II dynamics at developmental promoters and enhancers by Chris Ke Bai, Gopal Chovatiya, Emily Janine Pollack, Yu-Ching Liao, Ashley Nayeon Kim, Tudorita Tumbar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13377180.txt.
Description
Chris Ke Bai and co-authors present a study dated 2026 on how a chemical tag on DNA packaging shapes skin formation. The tag, called H3K9me3, silences stray genes and repeats in early embryos. Its role in building organs later in development was less clear.
The team removed the tag's three writer enzymes from the embryonic mouse skin layer. Skin cells then failed to mature, the barrier never formed, and hair follicles and touch cells did not appear. Single-cell data showed mixed-up cell identities and stray gene programs. The tag works mainly by holding back the start of gene reading at key control sites. All three enzymes were needed together, marking the tag as a core driver of skin development.
Catalog record
| CREATOR | Chris Ke Bai, Gopal Chovatiya, Emily Janine Pollack, Yu-Ching Liao, Ashley Nayeon Kim, Tudorita Tumbar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |