Exploring the emerging role of CRISPR-Cas systems in probiotic development
Abrar Hussain, Naheed Mojgani, Maria Fareed Siddiqui, Mohammad Inam Khan, Syed Abid Ali · 2026
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Description
Hussain and colleagues review how CRISPR-Cas gene editing, taken from bacteria's immune system, improves probiotic germs, in 2026 research. Probiotics are live microbes taken for health gains, and lactic acid bacteria are the mainstays of the field. Over 40 percent of those bacterial species carry CRISPR-Cas systems, giving engineers an editing tool already in the cell. The review lists uses across medicine, farming, food production, and industry that build on this machinery.
Editing strategies fall into additive, subtractive, and modulatory classes: adding new functions, deleting unwanted genes, or retuning how strongly genes are expressed. Examples include swapping slow gene promoters for efficient ones to boost output of compounds. The authors argue CRISPR's precision and speed let teams enhance acid tolerance, gut survival, and germ-killing output beyond what strain selection alone achieves. Hussain frames genome-edited probiotics as a fast-growing frontier needing safety frameworks to match.
Catalog record
| CREATOR | Abrar Hussain, Naheed Mojgani, Maria Fareed Siddiqui, Mohammad Inam Khan, Syed Abid Ali |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |