Targeting collagen biosynthesis by small molecules inhibiting the function of the peptide-substrate-binding domain of collagen prolyl 4-hydroxylases
Bukunmi Adediran, Carlos Vela-Rodríguez, Sudarshan Murthy, M Mubinur Rahman, Rik K Wierenga, Lari Lehtiö, M Kristian Koski · 2026
Read Targeting collagen biosynthesis by small molecules inhibiting the function of the peptide-substrate-binding domain of collagen prolyl 4-hydroxylases by Bukunmi Adediran, Carlos Vela-Rodríguez, Sudarshan Murthy, M Mubinur Rahman, Rik K Wierenga, Lari Lehtiö, M Kristian Koski (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13377042.txt.
Description
Bukunmi Adediran and six co-authors hunt small molecules that block collagen build at a fresh site. Their paper is from two thousand twenty-six. Collagen needs a hydroxylase enzyme to form, and excess collagen drives fibrosis and helps cancers. Known blockers hit the enzyme's core site, which many like enzymes share, so they lack aim.
The team aims at the enzyme's peptide-grip domain, a part this family alone holds. They build a glow-based screen and run a large mimic library through it for two forms of the enzyme. One hit blocks both forms and slows the full enzyme in tests. The screen opens a route to more aimed drugs for fibrotic disease and cancer.
Catalog record
| CREATOR | Bukunmi Adediran, Carlos Vela-Rodríguez, Sudarshan Murthy, M Mubinur Rahman, Rik K Wierenga, Lari Lehtiö, M Kristian Koski |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |