Resistance to tumorigenesis in the african spiny mouse (Acomys) correlates with upregulation of multiple tumor suppressor genes
Marta Vitorino, Gonçalo G. Pinheiro, Inês Grenho, Ines M. Araujo, Bibiana I. Ferreira, Wolfgang Link, Gustavo Tiscornia · 2026
Read Resistance to tumorigenesis in the african spiny mouse (Acomys) correlates with upregulation of multiple tumor suppressor genes by Marta Vitorino, Gonçalo G. Pinheiro, Inês Grenho, Ines M. Araujo, Bibiana I. Ferreira, Wolfgang Link, Gustavo Tiscornia (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13376787.txt.
Description
Marta Vitorino and co-authors wrote a 2026 paper on a mouse that seems to resist cancer. The African spiny mouse is known for healing wounds and regrowing tissue in ways most mammals cannot. The team asked whether that gift comes with protection against tumors, and what genes might explain it.
They painted the skin of spiny mice and normal lab mice with chemicals known to cause growths. Both kinds showed DNA damage, cell growth, and immune cells moving in. Yet only the normal mice grew tumors, while the spiny mice stayed free of them. Gene readings showed the spiny mouse switched on many defense genes, including several that are known to block tumors. The contrast points to paths that cancer research could borrow.
Catalog record
| CREATOR | Marta Vitorino, Gonçalo G. Pinheiro, Inês Grenho, Ines M. Araujo, Bibiana I. Ferreira, Wolfgang Link, Gustavo Tiscornia |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |