The biological clock in parkinson’s disease: mechanisms and chronotherapy
Hong Liu, Hao Ling, Kangchao Sun, Kun Yang, Wenzhen Du, Yuxiu Ma, Yaru Wang, Kai Wang, Ying Liu, Long Niu · 2026
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Description
Hong Liu and colleagues review how the body daily clock interacts with Parkinson disease. Parkinson is the second most common degenerative brain disease, marked by loss of dopamine-making cells and clumps of a sticky protein. Sleep and rhythm problems are common in patients, and growing evidence suggests clock disruption may help drive the disease rather than merely follow it. Writing in twenty twenty-six, the review gathers the mechanisms proposed so far, in animal and human work, and weighs the quality of that evidence.
The second half turns to chronotherapy, the idea of timing treatment to the clock. Aligning drug dosing, light, and daily routines with body rhythms might raise benefit, cut side effects, and allow more personal care plans. The authors present clock-aware care as a promising but still developing direction for Parkinson management.
Catalog record
| CREATOR | Hong Liu, Hao Ling, Kangchao Sun, Kun Yang, Wenzhen Du, Yuxiu Ma, Yaru Wang, Kai Wang, Ying Liu, Long Niu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |