Multi-region proteomic mapping identifies FTL1 and SERPINA3K as protective factors in cardiac aging
Jingnan Huang, Xin Sun, Huadong Liu, Kunpeng Li, Xin Liu, Yunmeng Bai, Zhiyu Dong, Xinlei Wu, Xinyi Liu, Lin Jia, Jianlong Yan, Lixin Cheng, Jigang Wang, Lingyun Dai, Qingshan Geng · 2026
Read Multi-region proteomic mapping identifies FTL1 and SERPINA3K as protective factors in cardiac aging by Jingnan Huang, Xin Sun, Huadong Liu, Kunpeng Li, Xin Liu, Yunmeng Bai, Zhiyu Dong, Xinlei Wu, Xinyi Liu, Lin Jia, Jianlong Yan, Lixin Cheng, Jigang Wang, Lingyun Dai, Qingshan Geng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13376365.txt.
Description
Jingnan Huang and colleagues map region-specific protein changes in ageing hearts in a 2026 study. Ageing drives heart decline and diseases such as infarction and heart failure, yet spatially resolved ageing proteomics were incomplete. The team profiled multiple mouse heart regions at 3, 12, and 20 months, quantifying 6,650 proteins.
Two proteins, FTL1 and SERPINA3K, showed strong age-linked changes across all regions. Knocking down Ftl1 triggered heart muscle cell ferroptosis and senescence, rescued by the ferroptosis blocker Ferrostatin-1. Depleting Serpina3k worsened senescence and collagen build-up through the cGAS-STING-PERK axis, reversible by restoring Serpina3k or blocking downstream signals. The pair emerge as protective factors whose loss accelerates cardiac ageing.
Catalog record
| CREATOR | Jingnan Huang, Xin Sun, Huadong Liu, Kunpeng Li, Xin Liu, Yunmeng Bai, Zhiyu Dong, Xinlei Wu, Xinyi Liu, Lin Jia, Jianlong Yan, Lixin Cheng, Jigang Wang, Lingyun Dai, Qingshan Geng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |