Synthesis and anti-antileishmanial profile of novel thiazolidine-4-one derivatives and molecular docking and molecular dynamics simulations studies
Soheila Molaei, Jafar Abbasi Shiran, Arina Esmailzadeh, Soroush Rajabi, Mohammad Reza Rahimi, Yasamin Abedini Zal, Saghi Sepehri · 2026
Read Synthesis and anti-antileishmanial profile of novel thiazolidine-4-one derivatives and molecular docking and molecular dynamics simulations studies by Soheila Molaei, Jafar Abbasi Shiran, Arina Esmailzadeh, Soroush Rajabi, Mohammad Reza Rahimi, Yasamin Abedini Zal, Saghi Sepehri (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13376208.txt.
Description
Soheila Molaei and colleagues report a two thousand twenty-six study of new compounds against leishmaniasis, a neglected parasite disease. The infection threatens hundreds of millions across many countries. Existing drugs are few and flawed.
Seven new thiazolidine-based compounds were synthesized and tested on the parasite's two life stages. All slowed the free-swimming stage, with three clearly strongest. The same leaders worked, more weakly, against the form hiding inside cells. Safety was checked on immune cells, and death pathways were measured. Computer docking and motion simulations explored how the best compounds bind parasite targets.
Catalog record
| CREATOR | Soheila Molaei, Jafar Abbasi Shiran, Arina Esmailzadeh, Soroush Rajabi, Mohammad Reza Rahimi, Yasamin Abedini Zal, Saghi Sepehri |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 121 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |