GraphChIAr: genome-wide super-resolution reconstruction of protein-mediated remote chromatin interactions by augmenting hi-C interaction maps with multiple ChIP-seq profiles
Hao Dong, Guo-Zheng Rao, Hao-Yu Wang, Xin-Ran Wu, Tong Xian, Bo-Qiang Wang, Pu-Feng Du · 2026
Read GraphChIAr: genome-wide super-resolution reconstruction of protein-mediated remote chromatin interactions by augmenting hi-C interaction maps with multiple ChIP-seq profiles by Hao Dong, Guo-Zheng Rao, Hao-Yu Wang, Xin-Ran Wu, Tong Xian, Bo-Qiang Wang, Pu-Feng Du (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13376144.txt.
Description
Hao Dong and co-authors built a deep learning tool to sharpen maps of chromatin contacts in two thousand twenty-six. Proteins that bind DNA mediate long-range contacts that control genes. Direct lab methods for such contacts are costly and scarce, and earlier models had limited resolution.
Their framework, GraphChIAr, starts from Hi-C contact maps and adds many protein binding profiles plus sequence data. It can estimate contact strength down to near-nucleosome resolution, far finer than the input. A shift-distance feature lets it predict contacts between distant genome sites across the whole genome. Checks against known mediators like CTCF showed high accuracy. Code is publicly available.
Catalog record
| CREATOR | Hao Dong, Guo-Zheng Rao, Hao-Yu Wang, Xin-Ran Wu, Tong Xian, Bo-Qiang Wang, Pu-Feng Du |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |