Functional and mechanistic inactivation of immune hubs orchestrates tumor development and progression in lung adenocarcinoma
Abdullah Alghamdi, Mohammed Alissa · 2026
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Description
Abdullah Alghamdi and colleagues identify silenced immune hubs in lung adenocarcinoma in a 2026 study. Lung adenocarcinoma is the most common non-small cell lung cancer and a leading cause of cancer death, yet survival stays poor despite targeted and immune therapies. The team pulled 1,284 immune genes from ImmPort, built a protein interaction network, and pinpointed hub genes.
Four hubs emerged: IFNG, TNF, CD4, and CD8A, all significantly downregulated in tumours and cell lines, with diagnostic value on ROC analysis. Methylation and copy number changes linked to their repression. Overexpression experiments in A549 and H1299 cells tested effects on growth, colony formation, migration, and xenograft tumours. The work frames immune hub silencing as a driver of lung tumour growth and a biomarker set for prognosis.
Catalog record
| CREATOR | Abdullah Alghamdi, Mohammed Alissa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |