GLUT9b- and ABCG2-mediated collecting duct urate transport uncovers a vasopressin-independent mechanism of renal water reabsorption
Mohamad Hadla, Jean Marc Mardirossian, Daniel G. Bichet, Abdul Hamid Borghol, Georges Abboud, Ahmad Ghanem, Eduardo Chini, Peter Harris, Vicente E. Torres, Seth L. Alper, Volker Vallon, Fouad T. Chebib · 2026
Read GLUT9b- and ABCG2-mediated collecting duct urate transport uncovers a vasopressin-independent mechanism of renal water reabsorption by Mohamad Hadla, Jean Marc Mardirossian, Daniel G. Bichet, Abdul Hamid Borghol, Georges Abboud, Ahmad Ghanem, Eduardo Chini, Peter Harris, Vicente E. Torres, Seth L. Alper, Volker Vallon, Fouad T. Chebib (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13374851.txt.
Description
Mohamad Hadla and co-authors found a salt-free path for kidney water take-back in a 2026 study. The known path uses a hormone that tells the kidney to hold water. Their path turns on fruit sugar kin called urate, held in kidney duct cells.
Two gate proteins set the urate load, one that lets it in and one that lets it out. A load rise lit a chain that parked the water gate at the cell face, with no hormone call. A drug that blocks the out gate raised take-back in live tests. The path may one day aid folk whose hormone path is broke.
Catalog record
| CREATOR | Mohamad Hadla, Jean Marc Mardirossian, Daniel G. Bichet, Abdul Hamid Borghol, Georges Abboud, Ahmad Ghanem, Eduardo Chini, Peter Harris, Vicente E. Torres, Seth L. Alper, Volker Vallon, Fouad T. Chebib |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58209 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |