Thyroid hormone regulatory system in the mouse retina: integrated transcriptional and translational analysis of deiodinase enzymes, thyroid hormone receptors and thyroid hormone transporters
Alberto Melecchi, Elisa Angeloni, Silvana Balzan, Sara Calcagno, Alessio Canovai, Francesca Forini, Franziska Brinkmann, Matteo Lulli, Giuseppina Nicolini, Chiara Posarelli, Milena Rizzo, Rosario Amato, Giovanni Casini · 2026
Read Thyroid hormone regulatory system in the mouse retina: integrated transcriptional and translational analysis of deiodinase enzymes, thyroid hormone receptors and thyroid hormone transporters by Alberto Melecchi, Elisa Angeloni, Silvana Balzan, Sara Calcagno, Alessio Canovai, Francesca Forini, Franziska Brinkmann, Matteo Lulli, Giuseppina Nicolini, Chiara Posarelli, Milena Rizzo, Rosario Amato, Giovanni Casini (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13374361.txt.
Description
Alberto Melecchi and co-authors present a 2026 study of thyroid hormone control inside the mouse retina. The hormone guides growth and energy use, and the retina burns energy at a high rate. Genes that tune the hormone, sense it, and carry it are all found in the eye, but their map was patchy. The team set out to chart each part's place and role.
The group first mined single-cell data from mouse and human retinas to predict where each part sits. Wet lab checks in mouse eyes then confirmed the spots with tagged RNA and protein stains. The team also summed up what goes wrong in mice that lack one part each. A full map of the system helps explain eye diseases tied to hormone swings.
Catalog record
| CREATOR | Alberto Melecchi, Elisa Angeloni, Silvana Balzan, Sara Calcagno, Alessio Canovai, Francesca Forini, Franziska Brinkmann, Matteo Lulli, Giuseppina Nicolini, Chiara Posarelli, Milena Rizzo, Rosario Amato, Giovanni Casini |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 85 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |