Autoimmune diseases and risk of adverse pregnancy outcomes: a population-based cohort study of five million pregnancies in the UK
Megha Singh, Anuradhaa Subramanian, Steven Wambua, Neil Cockburn, Stephanie J Hanley, Siang Ing Lee, Arturo Gonzalez-Izquierdo, Mairead Black, John A Reynolds, Francesca L Crowe, Krishnarajah Nirantharakumar · 2026
Read Autoimmune diseases and risk of adverse pregnancy outcomes: a population-based cohort study of five million pregnancies in the UK by Megha Singh, Anuradhaa Subramanian, Steven Wambua, Neil Cockburn, Stephanie J Hanley, Siang Ing Lee, Arturo Gonzalez-Izquierdo, Mairead Black, John A Reynolds, Francesca L Crowe, Krishnarajah Nirantharakumar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13374351.txt.
Description
Megha Singh and co-authors link autoimmune diseases with pregnancy risks in a 2026 study of United Kingdom records. Autoimmune conditions are growing more common among pregnant women, but solid evidence on outcomes was scattered. The team used linked primary care and hospital data covering more than five million pregnancies between 2000 and 2022.
They tested seventeen autoimmune diseases against twelve outcomes, with care taken for false alarms from so many comparisons. Women with autoimmune disease faced higher risk across every outcome studied. Some links stood out sharply: severe vomiting in pregnancy with Addison's disease, high blood pressure and diabetes of pregnancy with type 1 diabetes, and early birth with rheumatoid arthritis. Babies small for their age and stillbirth were more common with lupus. Mental health problems after birth also rose across several diseases.
Catalog record
| CREATOR | Megha Singh, Anuradhaa Subramanian, Steven Wambua, Neil Cockburn, Stephanie J Hanley, Siang Ing Lee, Arturo Gonzalez-Izquierdo, Mairead Black, John A Reynolds, Francesca L Crowe, Krishnarajah Nirantharakumar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |