m6A-modificated Linc00707 promotes the progression of TNBC via U2AF2-mediated alternative splicing of ATG4B
Hongli Li, Yong Li, Qinghua Liu, Chonggao Yin, Yunxiang Zhang, Peng Gao · 2026
Read m6A-modificated Linc00707 promotes the progression of TNBC via U2AF2-mediated alternative splicing of ATG4B by Hongli Li, Yong Li, Qinghua Liu, Chonggao Yin, Yunxiang Zhang, Peng Gao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13374319.txt.
Description
Hongli Li and five co-authors trace how a long non-coding RNA drives an aggressive breast cancer in a study from 2026. Triple-negative breast cancer lacks the usual drug targets, so its control points matter. The RNA, named Linc00707, was already tied to this cancer, but what switches it on and what it does inside cells were unclear.
A gene regulator called FOXP3 switches the RNA on, and a chemical mark steadies it. The RNA then binds a splicing factor and changes how a cell-cleaning gene is spliced, helping tumor cells grow and invade. Short strands designed to block that binding weakened the effect in cells and mouse tumors.
Catalog record
| CREATOR | Hongli Li, Yong Li, Qinghua Liu, Chonggao Yin, Yunxiang Zhang, Peng Gao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |