Discovery of a novel cannabidiol-derived transient receptor potential vanilloid 4 inhibitor to reduce pulmonary edema and lung vascular permeability in mice
Yassir Arfath, Pankaj Singh Cham, Tusharika Kotra, Rahila Akhter, Sumeer Ahmed, Mandeep Kour, Sheikh Tasduq Abdullah, Parvinder Pal Singh, Sheikh Rayees, Zabeer Ahmed · 2026
Read Discovery of a novel cannabidiol-derived transient receptor potential vanilloid 4 inhibitor to reduce pulmonary edema and lung vascular permeability in mice by Yassir Arfath, Pankaj Singh Cham, Tusharika Kotra, Rahila Akhter, Sumeer Ahmed, Mandeep Kour, Sheikh Tasduq Abdullah, Parvinder Pal Singh, Sheikh Rayees, Zabeer Ahmed (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13374314.txt.
Description
Yassir Arfath and a large team report a new drug, drawn from cannabidiol, that may guard the lung in acute injury. Their paper is from two thousand twenty-six. In acute lung injury, a channel called TRPV4 opens and lets fluid leak into the lung. Blocking that channel can cut swelling and keep air flow up.
They design and screen a set of such blockers, then test the lead one in mouse models of lung injury. The drug stops lung swelling and keeps the vessel wall intact. It cuts the rush of immune cells and the release of swelling signals. It also calms a set of pathways that drive swelling. The lead looks strong for later study.
Catalog record
| CREATOR | Yassir Arfath, Pankaj Singh Cham, Tusharika Kotra, Rahila Akhter, Sumeer Ahmed, Mandeep Kour, Sheikh Tasduq Abdullah, Parvinder Pal Singh, Sheikh Rayees, Zabeer Ahmed |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |