Early detection of gastric cancer with the assistance of cell-free DNA fragmentomics
Xiaoli Huang, Zhengxiang Han, Ying Zhang, Hongmei Wang, Xuqi Li, Chenxi Bai, Ying Pan, Jingwen Huang, Jiaojiao Xie, Xiaohan Qian, Xuan Wang, Tao Ding, Jinpeng Zhang, Shanshan Yang, Xinyue Hong, Qifan Jing, Gang Li, Xiaohua Li · 2026
Read Early detection of gastric cancer with the assistance of cell-free DNA fragmentomics by Xiaoli Huang, Zhengxiang Han, Ying Zhang, Hongmei Wang, Xuqi Li, Chenxi Bai, Ying Pan, Jingwen Huang, Jiaojiao Xie, Xiaohan Qian, Xuan Wang, Tao Ding, Jinpeng Zhang, Shanshan Yang, Xinyue Hong, Qifan Jing, Gang Li, Xiaohua Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13374216.txt.
Description
Xiaoli Huang and others build a blood test for early stomach cancer using cell-free DNA patterns in a 2026 study. Early gastric cancer often causes no clear symptoms, so most patients are found late with poor survival. The team profiled cell-free DNA by low-depth whole genome sequencing, extracting fragment size patterns, gene reading factor binding coverage, and methylation patterns.
Those features were paired in a stacked machine learning model. Training, time-separated validation, and external cohorts from two centres were used, with areas under the curve above 0.96 in each cohort. The test distinguishes early cancers from healthy controls without invasive procedures. If confirmed in larger screening trials, it could shift gastric cancer detection far earlier.
Catalog record
| CREATOR | Xiaoli Huang, Zhengxiang Han, Ying Zhang, Hongmei Wang, Xuqi Li, Chenxi Bai, Ying Pan, Jingwen Huang, Jiaojiao Xie, Xiaohan Qian, Xuan Wang, Tao Ding, Jinpeng Zhang, Shanshan Yang, Xinyue Hong, Qifan Jing, Gang Li, Xiaohua Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |