Personalized barrier recovery induced by Lactobacillus helveticus SBT2171 in an In Vitro model of ulcerative colitis-derived fecal supernatants
Melika Khademi, Nesa Kazemifard, Mohadese Fathi, Maryam Farmani, Shaghayegh Baradaran Ghavami, Binazir Khanabadi, Shabnam Shahrokh · 2026
Read Personalized barrier recovery induced by Lactobacillus helveticus SBT2171 in an In Vitro model of ulcerative colitis-derived fecal supernatants by Melika Khademi, Nesa Kazemifard, Mohadese Fathi, Maryam Farmani, Shaghayegh Baradaran Ghavami, Binazir Khanabadi, Shabnam Shahrokh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13374120.txt.
Description
Melika Khademi and colleagues test whether a probiotic strain can restore gut barrier function in ulcerative colitis models in a 2026 study. Barrier breakdown is a hallmark of inflammatory bowel disease, yet probiotic benefit varies by patient. Gut cells were exposed to stool fluid from three ulcerative colitis patients, which raised inflammatory IL-8 and lowered barrier genes Claudin-1 and MUC2.
Preparations of Lactobacillus helveticus SBT2171, including live bacteria, cell-free fluid, and debris-containing fluid, were then tested at 24 and 48 hours. Restoration of barrier genes was partial and depended on both patient source and preparation. Live bacteria gave transient or sustained Claudin-1 gains by source, while cell-free fluid gave broader, more durable gains. The work argues for personalised probiotic choices rather than one-size-fits-all dosing.
Catalog record
| CREATOR | Melika Khademi, Nesa Kazemifard, Mohadese Fathi, Maryam Farmani, Shaghayegh Baradaran Ghavami, Binazir Khanabadi, Shabnam Shahrokh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |