Structurally defining neurokinin selectivity to improve NK2R agonists
Artem Pavlovskyi, Yinhang Ren, María Gestal-Mato, Ole H Olsen, Thue W Schwartz, Zachary Gerhart-Hines, Xiangyu Liu · 2026
Read Structurally defining neurokinin selectivity to improve NK2R agonists by Artem Pavlovskyi, Yinhang Ren, María Gestal-Mato, Ole H Olsen, Thue W Schwartz, Zachary Gerhart-Hines, Xiangyu Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13372656.txt.
Description
Artem Pavlovskyi and co-authors mapped a brain and gut signal switch in a 2026 study. The switch, when on, can cut hunger and raise body heat burn. That mix is prized in weight care, since most drugs now work by hunger cuts alone. The catch is that close kin switches cause side harms.
The team froze the switch with its key bound in place and read the shapes with a strong scope. Small tests then proved which touch points made the switch picky. The map shows how to build new drugs that hit just this switch. Such drugs could one day add heat burn to weight care, with fewer side harms.
Catalog record
| CREATOR | Artem Pavlovskyi, Yinhang Ren, María Gestal-Mato, Ole H Olsen, Thue W Schwartz, Zachary Gerhart-Hines, Xiangyu Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72760 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |