The Endocrine Disrupting Compounds Bisphenol‐A and α‐Zeranol Mimic the Estrogen Transcriptional Program to Promote Proliferation and Stemness in Breast Cancer Cells
Cassandra Winz, Eric Li, Caroline Xie, Kyo Chang Lee, Kevin Boguszewski, Shlok Rohatagi, Rita Hahn, Ray Rancourt, Philip Furmanski, Nanjoo Suh · 2026
Read The Endocrine Disrupting Compounds Bisphenol‐A and α‐Zeranol Mimic the Estrogen Transcriptional Program to Promote Proliferation and Stemness in Breast Cancer Cells by Cassandra Winz, Eric Li, Caroline Xie, Kyo Chang Lee, Kevin Boguszewski, Shlok Rohatagi, Rita Hahn, Ray Rancourt, Philip Furmanski, Nanjoo Suh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13372423.txt.
Description
Cassandra Winz and co-authors show in 2026 that two hormone-disrupting chemicals act like estrogen in breast cancer cells. The chemicals, bisphenol-A from plastics and alpha-zeranol, latch onto the estrogen receptor. The team tested them on breast cancer lines that do or do not carry that receptor. Growth rose only in receptor-carrying cells, and a receptor blocker undid the effect.
Gene-reading showed both chemicals switching on estrogen's target genes and widening the pool of stem-like cancer cells. Their gene patterns closely overlapped estrogen's own. The study gives the first full gene-level portrait of alpha-zeranol in this setting. It sharpens concern over everyday exposures feeding this cancer type.
Catalog record
| CREATOR | Cassandra Winz, Eric Li, Caroline Xie, Kyo Chang Lee, Kevin Boguszewski, Shlok Rohatagi, Rita Hahn, Ray Rancourt, Philip Furmanski, Nanjoo Suh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |