EphA2/SHP2/SOX8 Axis: A Novel Target for Regulation of Migration and Cetuximab Treatment Sensitivity in Oral Squamous Cell Carcinoma
Dayong Yan, Lele Guo, Fei Pei, Ketao Zhong · 2026
Read EphA2/SHP2/SOX8 Axis: A Novel Target for Regulation of Migration and Cetuximab Treatment Sensitivity in Oral Squamous Cell Carcinoma by Dayong Yan, Lele Guo, Fei Pei, Ketao Zhong (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13372410.txt.
Description
Dayong Yan and colleagues trace a signalling chain that drives mouth cancer spread and drug resistance in a 2026 study. Oral squamous cell carcinoma often resists therapy, and the protein EphA2 was suspected of worsening it. Cell lines with EphA2 and SOX8 raised or lowered were tested with cetuximab, using migration, invasion, and binding assays plus a mouse tumour model.
EphA2 was high in cancer cells and raised SOX8 levels. Through SOX8, EphA2 increased migration and invasion. Lowering EphA2 made cells more sensitive to cetuximab, while raising SOX8 blunted that sensitivity. The protein SHP2 bound EphA2 in the chain. The axis offers a target for restoring drug response in resistant mouth cancers.
Catalog record
| CREATOR | Dayong Yan, Lele Guo, Fei Pei, Ketao Zhong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |