JAK-STAT signaling pathway in cancer: from molecular mechanisms to clinical intervention
Xiaoqian Zhang, Penghui Li, Fuqiang Ma, Tuokai Wang, Qingfei Chu, Shihui Wei, Chen Xue, Ziming Wang, Juan Lu · 2026
Read JAK-STAT signaling pathway in cancer: from molecular mechanisms to clinical intervention by Xiaoqian Zhang, Penghui Li, Fuqiang Ma, Tuokai Wang, Qingfei Chu, Shihui Wei, Chen Xue, Ziming Wang, Juan Lu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13371724.txt.
Description
Xiaoqian Zhang and co-authors review a signaling pathway that plays a central role in cancer, in a 2026 paper. The JAK-STAT pathway carries signals from outside the cell to the nucleus, guiding growth, immune response, and tissue balance. When it stays switched on, tumors can grow, evade immunity, and resist treatment.
Beyond the classic route, the review covers newer findings: pathway proteins acting in organelles, forming droplets, shaping gene marks, and switching on without the usual trigger. Within the tumor setting, steady activation shapes links among cancer, immune, and support cells. The authors survey drugs that block the pathway's kinases or its STAT proteins directly. They also discuss gene based approaches still in development.
Catalog record
| CREATOR | Xiaoqian Zhang, Penghui Li, Fuqiang Ma, Tuokai Wang, Qingfei Chu, Shihui Wei, Chen Xue, Ziming Wang, Juan Lu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |